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It producesanesthesia in humans at concentrations of 3.6–6.5% in air,but respiratory arrest occurs at 7–10%, providing a smallmargin of safety.
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PBPK models are also used for examining theeffects of changing physiology on target tissue dosimetry, as inthe case of early life exposure where rapid organ growth anddevelopment of important metabolic enzymes affect chemicalkinetics. No such changes orresults were observed in comparable regions of Cuba that did not get thehomeopathic treatments No such changes orresults were observed in comparable regions of Cuba that did not get thehomeopathic treatments. The most rapid period of tracheal growthappears to occur during the ?rst 4 years of life(Wailoo and Emery 1982). However, its indications for thisdisease have since expanded to encompass treat-ment of symptoms including acute hypercapniaand respiratory muscle fatigue and to assist inkinesitherapy for improving diminished oxygensaturation.
Forthe most part, older people have diffi culty distinguishinghigher-frequency sounds, due to the neurosensory condi-tion of presbycusis, caused by atrophy of the cochlea anddegeneration of auditory neurons.